Surgical Oncology

Sentinel node biopsy is a surgical procedure used in Surgical Oncology to determine whether cancer has spread beyond the primary tumor. The sentinel nodes are the first few lymph nodes into which a tumor drains.

Sentinel Lymph Node Biopsy (SLNB) has been proven to improve outcomes for patients with early breast cancer, by avoiding unnecessary axillary lymph node dissections.

The standard method so far to detect the sentinel lymph node:

  • Uses injection of Technetium-99m, a radioisotope, and a gamma probe for detection (no visualization).
  • To visualize the node, a staining agent like blue dye is employed. Blue dye is known to cause tattooing of the skin.

Indocyanine green (ICG) Fluorescence imaging for SLNB has the same detection rate as Technetium-99m and Blue dye combined. It also provides intraoperative visualization.

ICG Fluorescence imaging provides real-time visualization of lymphatic channels and nodes without any harmful radiation. Unlike technetium-99m which has to be handled by radiation medicine personnel, ICG can be used by surgeons themselves.

.nm Fluorescence Imaging system is designed to empower surgeons in surgical oncology to independently perform the entire operation beginning from preparation of contrast agent to identifications and removal of sentinel nodes.


Can low-cost indocyanine green florescence technique for sentinel lymph node biopsy replace dual dye (radio-colloid and blue dye) technique in early breast cancer: a prospective two-arm comparative study

Somashekhar SP, Kumar CR, Ashwin KR, et al.; Clin Breast Cancer. 2020

A feasibility study (ICG-10) of indocyanine green (ICG) fluorescence mapping for sentinel lymph node detection in early breast cancer

Wishart, G.C. et al.; European Journal of Surgical Oncology , Volume 38 , Issue 8 , 651 - 656

Qiu, Si-Qi et al., Critical Reviews in Oncology / Hematology, Volume 123 , 83 - 94

Indocyanine green detects sentinel lymph nodes in early breast cancer

Liu J, Huang L, Wang N, Chen P.; J Int Med Res. 2017;45(2):514-524

Randomized comparison of near-infrared fluorescence imaging using indocyanine green and 99m technetium with or without patent blue for the sentinel lymph node procedure in breast cancer patients

van der Vorst, Joost R., et al.; Ann Surg Oncol. 2012;19(13):4104-11

Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers

Schaafsma BE, Verbeek FP, Peters AA, et al.; BJOG. 2013;120(6):758-64

Peng H, Wang SJ, Niu X, Yang X, Chi C, Zhang G.; World J Surg Oncol. 2015;13:278

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