Surgical Oncology

  • Sentinel node biopsy is a surgical procedure used in Surgical Oncology to determine whether cancer has spread beyond the primary tumor. The sentinel nodes are the first few lymph nodes into which a tumor drains.

  • Sentinel Lymph Node Biopsy (SLNB) has been proven to improve outcomes for patients with early breast cancer, by avoiding unnecessary axillary lymph node dissections.

  • The standard method so far to detect the sentinel lymph node

  • Uses injection of Technetium-99m, a radioisotope, and a gamma probe for detection (no visualization).
  • To visualize the node, a staining agent like blue dye is employed. Blue dye is known to cause tattooing of the skin.
  • Indocyanine green (ICG) Fluorescence imaging for SLNB has the same detection rate as Technetium-99m and Blue dye combined. It also provides intraoperative visualization.

  • ICG Fluorescence imaging provides real-time visualization of lymphatic channels and nodes without any harmful radiation. Unlike technetium-99m which has to be handled by radiation medicine personnel, ICG can be used by surgeons themselves.

  • .nm Fluorescence Imaging system is designed to empower surgeons in surgical oncology to independently perform the entire operation beginning from preparation of contrast agent to identifications and removal of sentinel nodes.


Surgical Oncology References

A feasibility study (ICG-10) of indocyanine green (ICG) fluorescence mapping for sentinel lymph node detection in early breast cancer

Wishart, G.C. et al.

European Journal of Surgical Oncology , Volume 38 , Issue 8 , 651 – 656


Evolution in sentinel lymph node biopsy in breast cancer

Qiu, Si-Qi et al.

Critical Reviews in Oncology / Hematology , Volume 123 , 83 – 94

Liu J, Huang L, Wang N, Chen P. Indocyanine green detects sentinel lymph nodes in early breast cancer.

J Int Med Res. 2017;45(2):514-524.

Randomized Comparison of Near-infrared Fluorescence Imaging Using Indocyanine Green and 99m Technetium With or Without Patent Blue for the Sentinel Lymph Node Procedure in Breast Cancer Patients

Ann Surg Oncol. 2012;19(13):4104-11.

Schaafsma BE, Verbeek FP, Peters AA, et al. Near-infrared fluorescence sentinel lymph node biopsy in vulvar cancer: a randomised comparison of lymphatic tracers

BJOG. 2013;120(6):758-64.

Peng H, Wang SJ, Niu X, Yang X, Chi C, Zhang G. Sentinel node biopsy using indocyanine green in oral/oropharyngeal cancer.

World J Surg Oncol. 2015;13:278.

For demo of .nm and more information

Irillic, a healthcare startup, has conceptualized, 
designed and developed an advanced
near-infrared Fluorescence Imaging System, 
Irillic .nm, that will prove to be a boon
for surgeons.

Irillic Pvt.Ltd.
#76, 10th Cross, 29th Main, 1st Phase,
Bangalore -560078 INDIA
T: +91 7624973228
E: info@irillic.com